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凡德他尼 Vandetanib Vandetanib is an orally bioavailable 4-anilinoquinazoline. Vandetanib selectively inhibits the tyrosine kinase activity of vascular endothelial growth factor receptor 2 (VEGF2),

索拉非尼 Sorafenib Sorafenib is a synthetic compound targeting growth signaling and angiogenesis.

帕唑帕尼 Pazopanib Pazopanib is an approved drug, is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity.

樂伐替尼 Lenvatinib Lenvatinib,also known as E7080,is a synthetic,orally available inhibitor of vascular endothelial growth factor receptor 2(VEGFR2)tyrosine kinase with potential antineoplastic activity.

卡博替尼 Cabozantinib Cabozantinib, also known as XL-184 or BMS-907351, is an orally bioavailable, small molecule receptor tyrosine kinase (RTK) inhibitor with potential antineoplastic activity.